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It also exerts a pro-inflammatory effect by promoting IL-1 secretion from macrophages [203]

Non-targeted CRISPR screen For the purposes of this analysis, non-targeted CRISPR screens refer to genome-wide screens which do not impose external conditions which may bias genomic reads

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Simultaneously, through the addition of a third component, it can weaken or remove the side-effects of drugs, or increase the effect of pharmacology through a combination of drugs

Smith PD, Smythies LE, Mosteller-Barnum M, Sibley DA, Russell MW, Merger M, Sellers MT, Orenstein JM, Shimada T, Graham MF, Kubagawa H: Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities

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