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Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes
SOD protects cells from the pro-oxidant action of the superoxide free radical 17 , thus a reduced SOD protection may translate in increased protein oxidative damage
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Additionally, PHMG negatively impacts liver function, heart activity (inducing procoagulant platelet activation), kidneys (causing mild hydropic changes in proximal tubules), and hematopoietic function, leading to changes in erythrocyte counts, hematocrit, and hemoglobin levels
