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Additionally, prolonged neuroinflammation may also induce functional alteration including sensory, motor and cognitive functions, etc

found no significant association between NOS3 rs1799983 polymorphism and HAPE susceptibility in Caucasians, 119 multiple studies in different geographical populations, including Japanese, 120 Chinese, 112,113 and Indian 121,122,123 populations, have highlighted a robust correlation between NOS3 rs1799983, rs199983, and rs7830 polymorphisms and HAPE risk

doi: 10.1038/s41467-024-54877-9

2024;3:e70025

Additionally, PEGs have been associated with immune responses, including complement activation and the formation of anti-PEG antibodies in certain contexts 179,180
The oncometabolite fumarate promotes pseudohypoxia through noncanonical activation of NF-kappaB signaling
