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[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Zimmerman J.W., Lindermuth J., Fish P.A., Palace G.P., Stevenson T.T., DeMong D.E

In the United States, it affects approximately 34.6% of the people, while in Europe, the prevalence ranges from 17.8 to 34.0%

[2] First identified in the 1970s, it has attracted scientific interest for its apparent roles in tissue repair, wound healing, and cellular regeneration

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however, senescent cells infamously secrete high levels of pro-inflammatory cytokines, chemokines, and extracellular matrix-degrading proteins that negatively impact the extracellular environment and induce spread of senescence to non-senescent cells (29-32)