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The activity of NOS was not affected by L-Arg or D-Arg in various organs such as the aorta, ileum, liver, kidney, lungs, brain and skeletal muscle (Table 4)

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Following ALC co-administration, the immobility time was remarkably decreased

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61,62 One of the major limitations of this study was the low number of patients and the absence of a placebo arm, prompting a placebo-controlled AST-120 Used to Treat Mild Hepatic Encephalopathy (ASTUTE) clinical trial, 63 a multicenter, double-blind RCT that randomized 148 patients with compensated cirrhosis to receive either dose-ranging oral AST-120 (2 or 4 g three times per day) vs

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