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Progression independent of relapse activity (PIRA) Progression independent of relapse activity indicating accumulation of irreversible clinical disability and CNS demyelination in the absence of overt inflammatory relapses

On the antioxidant front, GHK-Cu increases superoxide dismutase (SOD) activity through copper cofactor delivery, elevates catalase activity for hydrogen peroxide breakdown, and increases total glutathione levels

[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Qi J., Kim J.-W., Zhou Z., Lim C.-W., Kim B

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Both BP and propolis are rich in trace elements, flavonoids, and other healthy components and have been shown to have many health benefits, such as anti-allergic and anti-inflammatory properties (112)