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Wounds displayed faster healing, decreased concentration of metalloproteinases 2 and 9 as well as of TNF- (a major inflammatory cytokine) compared with vehicle alone or with untreated wounds [25]

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For silencing FOXO4, specific small interfering RNA (siRNA) was employed, with a negative control siRNA, and transfection was conducted using Lipofectamine 3000 [2]

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The benefits of this targeted approach are substantial: Peptides concentrate exactly where you need themin the injured joint