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It uses a methyl group donated by S-adenosylmethionine (SAM) to methylate nicotinamide a vitamin B3 form that would otherwise be recycled back into NAD+

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Cyanocobalamin is the form of vitamin B12 with the longest clinical history

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Long-Term Safety Considerations: While safety data from clinical trials spanning up to 24 weeks is reassuring, long-term safety data spanning years of continuous use remains limited

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