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The presence of resistance-associated substitutions (RAS) as natural polymorphisms in the NS5B gene affects HCV susceptibility to sofosbuvir and dasabuvir and may limit the clinical effectiveness of DAA combinations containing these drugs 45,46

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5-Amino-1MQ suits those studying a specific enzymatic fat metabolism mechanism

Previous melanocortin agonists that failed clinical trials for general obesity share common features that constrain their therapeutic windows, including low receptor potency, poor safety profiles, and suboptimal pharmacokinetics

Nail changes in patients infected with human immunodeficiency virus: a prospective controlled study
Pekala J, et al
