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Studies using adult human peripheral T cells demonstrated that glutamate at low concentrations ( 1 mM), however, this effect reversed, indicating that glutamate tends to have immunosuppressive properties at higher concentrations (176, 178)

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PAMAM dendrimers also show potential in delivering biomacromelucles, such as siRNA [129, 130]

J Gen Appl Microbiol 44:147152 Zhao H, Rubio B, Sapra P, Wu D, Reddy P, Sai P, Martinez A, Gao Y, Lozanguiez Y, Longley C, Greenberger LM, Horak ID (2008) Novel prodrugs of SN38 using multiarm poly(ethylene glycol) linkers

It activates the SIRT1/peroxisome proliferator-activated receptor-gamma coactivator 1 (PGC-1) pathway to promote mitochondrial biogenesis, regulate mitochondrial homeostasis, and inhibit the high mobility group protein (HMGB)1/TLR4/p38/extracellular regulated protein kinases (ERK)1/2 pathway to reduce inflammatory responses in CIA mice (259)