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These findings suggest that 4-HNE may play a role in the early stages of melanoma tumorigenesis, while its loss in metastases may be associated with the increased proliferative activity of metastatic cells [112]

doi: 10.3390/biom11070982

Since the circadian clock in these cells is directly light-sensitive and can be entrained by light-dark cycles, cells were synchronized to a 12:12 LD cycle for 7 days and then transferred into DD for at least 3 days

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Then, these rBFI time traces were aligned and averaged to compare the group response at different time gates

[DOI] [PubMed] [Google Scholar] 21.Hui W., Young D.A., Rowan A.D., Xu X., Cawston T.E., Proctor C.J