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Indeed it consists of two transmembrane domains, a large extracellular domain, and two short intracellular domains that are required for CD36 function after substrate binding (Su and Abumrad, 2009)

70 Differential Diagnosis Other diagnoses that psychiatric clinicians should evaluate before referring people to a sleep specialist on suspicion of a sleep disorder include hypersomnia related to a psychiatric disorder, substance- or medication-induced sleep disorder, history of infection, and circadian rhythm sleep-wake disorders (Table 1)

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Rodent models, however, permit controlled investigation of cellular and molecular mechanisms using transgenic manipulations that mimic human disease