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This chemotaxis allows tumor cells to move directionally through brain tissue, often toward vascularized areas, facilitating invasion (82)
rather, they represent adaptive programs that can be differentially engaged depending on treatment duration, tumor stage, and microenvironmental constraints to achieve better cellular fitness, including chemoresistance

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The economic calculation favours strict adherence to the 28-day limit wasted reagent is far cheaper than wasted time and animal models

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