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Adherence was evaluated with the Exercise Adherence Rating Scale (EARS) as the main measurement outcome, while the motivation was also reported through the Intrinsic Motivation Index (IMI), the balance through the mini-Balance Evaluation Systems Test (mini-BESTest), the gait with the Functional Gait Assessment (FGA) and the freezing effect during gait with the Freezing of Gait Questionnaire (FOG-Q)

Table 1) in adults and adolescents with SCD and a phase 1/2 open-label study (HIBISCUS- KIDS) in children with SCD are ongoing, with primary end points of hemoglobin response and annualized VOC rate (HIBISCUS) and pharmacokinetic assessments plus safety and tolerability (HIBISCUS-KIDS), respectively

Biotin Biotin is essential for producing keratin, the protein that strengthens hair, skin, and nails

Electron-beam irradiation (2 kGy) decreased folic acid levels by about 2030% in hamburgers and sausages fortified with folic acid 471,472

SIA is the modification of FIA technique to automate assays which is achieved by carrying out analyses in a flow system where a pump is used to continuously draw sample and reagent solutions into different lines or segments of plastic tubing, as well as push them forward through the system

Hindmarsh PC, Fall CH, Pringle PJ, Osmond C, Brook CG