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276,277 With the assistance of cholesterol transporter APOE, astrocyte-derived cholesterol could be transferred to neuronal membranes, regulating cholesterol-dependent lipid clusters (also known as lipid rafts) on neurons to promote A generation

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Rather than targeting IGF-IR/InsR themselves, an alternative strategy would be inhibition of the master regulators of RTKs or downstream signaling hubs such as IRS1/2 [205,206,207,208]

(ii) near-neutral or lightly anionic surface chemistry and PEGylation extend circulation while reducing acute cationic toxicity

Binding of glutathione to enterovirus capsids is essential for virion morphogenesis

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