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The SURPASS-3 MRI substudy added another layer, showing tirzepatide actually reduced muscle fat infiltration across all doses, indicating improved muscle quality even as total muscle volume decreased
& Smidt, M
Unlike peptides, this compound is not composed of amino acid chains and is produced via chemical synthesis rather than peptide assembly
The mechanisms of FA-induced insulin resistance have been intensively studied and have been attributed to two metabolites of FAs - DAGs and ceramides
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