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Regardless of this knowledge, metal emissions are still continuing, particularly in less developed countries [810]

The main environmental threats are associated with these non-essential elements because plants, as primary producers, form an important entry pathway for potentially toxic substances into the food chain [1,7]

Lu et al., 2012)

10.1016/j.bbagen.2012.10.005 Biochim Biophys Acta

NRF2 regulates heme degradation, thus removing excess amounts of the prooxidant molecule heme from the cellular pool

This helped to show that NNMT is a key target in metabolic research. Neelakantan and colleagues then expanded research involving small-molecule NNMT inhibitors