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Written informed consent was obtained from all participants prior to inclusion in the study

Therefore, RCTs with larger sample sizes and different races and regions are needed to strengthen the evidence regarding the positive effects of L-T4 in decreasing the miscarriage rate among thyroid autoantibody-positive women

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The American Diabetes Association recommends periodic B12 monitoring in patients on metformin, with annual monitoring for those on metformin more than 4 years