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173 ZhangK.WuL.ZhangP.LuoM.DuJ.GaoT.et al (2018)

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Specific amino acids serve distinct roles: glycine supports one-carbon metabolism and DNA synthesis, alanine provides metabolic substrates for energy production, and leucine regulates protein synthesis through mTOR signaling pathways [126,127,128]

Both mTORC1 and mTORC2 localize to multiple subcellular compartments, but mTORC1 is present mainly at the lysosomal membrane 34 and partially at the Golgi, 35 while mTORC2 can be found at the plasma membrane, outer mitochondrial membrane, and endosomal vesicles

Indeed, the components of this system are involved in the bi-directional transport of acyl moieties from cytosol to mitochondria and vice versa, thus playing a fundamental role in tuning the switch between the glucose and fatty acid metabolism

doi: 10.1186/s40779-023-00497-1