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The BoxBehnken design (BBD) and response surface modeling (RSM) were employed to determine the ideal conditions for the assay

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Mitochondria are directly involved in neuronal programmed cell death

Acknowledgements This work was supported by grants from the Fresco Parkinson Institute to New York University School of Medicine and The Marlene and Paolo Fresco Institute for Parkinsons and Movement Disorders, which were made possible with support from Marlene and Paolo Fresco (to VG, PC), by the Italian Ministry of Education, University and Research (MIUR)-2017ENN4F, and by the Italian Ministry of Health, Ricerca Corrente RC 2022

This restoration of GABAergic signaling helped in reducing glutamate excitotoxicity, nevertheless the improvements were modest compared to the effects observed with combination therapy

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