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Cys 2 ), cystine-free (Cys 2 -free), or cystine-free/GSH-supplemented (750 M) medium for the indicated time points were determined

J Transl Sci 7, doi: 10.15761/jts.1000458 (2021)

Dose adjustments may be necessary based on various clinical scenarios and patient-specific factors

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Your protocol calls for a 0.5mg dose

Two further phase II trials (280, 281) with larazotide acetate failed in finding an improvement in intestinal permeability, whereas the last trial published (282) underlined possible usefulness in refractory CD, defined as malabsorption and continued villous atrophy on duodenal biopsies despite strict avoidance of gluten for a minimum of 12 months (283)