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The literature search strategy is presented in Figure 2

A novel combination therapy using Rosuvastatin and lactobacillus combats dextran sodium sulfate-induced colitis in high-fat diet-fed rats by targeting the TXNIP/NLRP3 interaction and influencing gut microbiome composition

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2026 ASCO Gastrointestinal Cancers Symposium 44(2)

Besides, numerous studies have showed that inhibition of GPX4 could increase the sensitivity of chemotherapy, radiotherapy, immunotherapy and nanotherapy by inducing lipid peroxidation and ferroptosis [227,228,229]