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3 Subsequent studies with these animals revealed that Gpx4 is essential for maintaining tissue homeostasis by preventing cell demise and tissue damage in several organs including brain, skin, and endothelium

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By incorporating triggers such as pH, ROS, temperature, light, magnetic fields, or ultrasound, stimulus-responsive electrospun fibers can enable sustained release, on-demand dosing, or localized delivery

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Figure 3 4 Pathological links between EMT and pulmonary fibrosis EMT plays a central regulatory role in pulmonary fibrosis, characterized by remodeling of alveolar-epithelial phenotypes, down-regulation of epithelial markers (e.g., E-cadherin) and up-regulation of mesenchymal markers (e.g., vimentin, N-cadherin), together with fibroblast-to-myofibroblast differentiation that establishes a pro-fibrotic micro-environment and drives disease progression ( In pneumoconiosis (e.g., silicosis), AT2 cells similarly undergo EMT but with distinct upstream triggers