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doi: 10.1016/j.chembiol.2020.02.005 74 KanamoriHNaruseGYoshidaAMinatoguchiSWatanabeTKawaguchiTet al

Its a bioactive regenerative ingredient backed by clinical science and that requires careful formulation

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Neuron 109: 11681187.e13, 2021

These results highlight that targeting pathways involved in -KG production offers attractive therapeutically opportunities in diseases associated with macrophage malfunction

Combining both agents could theoretically amplify appetite suppression and gastrointestinal effects, though long-term safety data on this specific combination is lacking