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Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen

Indeed, up to two thirds of intracellular proteins may be phosphorylated at any given time, with phosphorylation often acting as an on/off switch for a large set of pathways involved in processes including metabolism, proliferation, apoptosis, and protein synthesis ( Residing at the blood-tissue interface of every organ system in the body, the vascular endothelium plays a critical role in multiple important physiologic processes

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This is a big risk for plaque in arteries

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