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Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease

Moreover, many studies showed that metformin improves the expression of BDNF by increasing the histone acetylation along with the BDNF promoter, which was attributed to the activation of AMPK and CREB (Ameen et al., 2022
Accumulation of MYOC in the trabecular meshwork caused by mutations leading to overproduction or reduced degradation is associated with increased IOP and, ultimately, with the development of glaucoma (Doucette et al., 2015)

doi: 10.1089/ars.2009.3074 41

Neurocognitive and Neuromuscular Rehabilitation Techniques After ACL Injury, Part 1: Optimizing Recovery in the Acute Post-Operative Phase-A Clinical Perspective
