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The SURPASS program (type 2 diabetes) enrolled more than 19,000 participants across 10 trials

These receptor proteins are characterized by the presence of LIR motifs for the interaction with ATG8 family proteins such as LC3 on the surface of phagophores, and many have ubiquitin-binding domains capable of recognizing ubiquitinated cargo, thus establishing a bridge between the cargo and the autophagic machinery (40, 92, 93)

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Thirdly, we had to exclude patients with specific characteristics based on justified exclusion criteria to minimize potential bias in the studys findings

Multi-pathway tissue regeneration signaling