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Goadsby, P

If one half cell is far from electrochemical equilibrium, its tendency to achieve equilibrium (i.e., to gain or lose electrons) can be used to alter the equilibrium position of a coupled half cell

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Default to conditions required by the least stable component
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Residual corpus cavernosum nNOS activity is essential for the erectile promoting actions of selective PDE5 inhibitors such as sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis)