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The mechanisms behind this upregulation appear to involve: Activation of the Nrf2 pathway, which controls the expression of various antioxidant enzymes including GR Modulation of cellular signaling cascades that respond to redox status Alteration of mitochondrial metabolism, influencing NADPH availability for GR activity Reduction of inflammatory signaling that can suppress antioxidant enzyme expression These effects suggest that hydrogen water may provide a "hormetic" stimulusa mild oxidative challenge that triggers beneficial adaptive responses in cellular antioxidant systems

Thus, the anti-inflammatory and neuroprotective action of luteolin may bring positive effects in schizophrenia that shares some features of neurodegenerative diseases [126]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Miele L., Valenza V., La Torre G., Montalto M., Cammarota G., Ricci R., Masciana R., Forgione A., Gabrieli M.L., Perotti G., et al

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16 Abraham JH, DeBakey SF, Reid L, Zhou J, Baird CP