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In a 72-week, double-blind phase 2 trial in patients with biopsy-confirmed NASH (legacy term) and fibrosis stage F1F3, once-daily subcutaneous semaglutide produced dose-dependent NASH resolution: 59% at the 0.4 mg dose versus 17% with placebo (a statistically significant difference)

BPC-157 is a signaling peptide that upregulates growth factors involved in tissue repair, particularly VEGF (new blood vessel formation), fibroblast activity (collagen production), and nitric oxide signaling