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It is plausible that the proposed ACR pathway can help explain why the control respiratory does not play a significant role in plants or why the over-expression of AOX can lead to increase of COX under specific stress conditions (Dahal and Vanlerberghe, 2017)

170 It involves an excessive inflammatory response in the lungs and breakdown of the alveolarcapillary barrier, resulting in the accumulation of high-protein edema fluid and the production and secretion of proteases and toxic mediators

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Additionally, the expression of genes related to the immunosuppressive functions of Treg cells (such as IL-10, CTLA-4, and TGF-) was downregulated, which weakened their ability to inhibit CD8 + T cell activity