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Practical take For clinicians, this reinforces a more nuanced approach: Match the drug to the patient profile Look beyond average weight loss alone Consider tolerability, adherence, comorbidities, access, and long-term strategy The obesity pipeline is getting deeperand that is good news for patients

Hypervolemic can occur for three reasons: i) Hyperglycemia causes extracellular compartment expansion as water is pulled from the intracellular space ii) The tonicity of the serum glucose causes profound thirst, which can lead to drastically increased oral intake (given thirst is usually considered suggestive of hypovolaemia, it is worth noting that this history finding is unhelpful in this exceptional setting) iii) Volume overload at baseline / missed dialysis sessions, etc

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Both cell alignment and shape of the nuclei elongated over time ( p = 0.066 and 0.0013, respectively) (Fig

To measure encapsidation, an aliquot of the cell lysate was used to infect fresh HeLa cells and, again, luciferase activity was measured at 6 hr post infection