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As a readout for PI3K activation, we measured phosphorylation of phosphoinositide-dependent kinase 1 (PDK1), which in turn is responsible for protein kinase B (AKT) phosphorylation at T308

Thus, lncRNA GDIL is a novel target to promote GSH degradation and augment platinum therapy
For example, IAV or SARS-CoV-2-induced NOX2 activity may suppress the TLR7-dependent antiviral response, thereby enhancing viral replication and pathogenicity 42,155
doi: 10.1016/s0925-4439(98)00081-7, 65

[DOI] [PubMed] [Google Scholar] [124]

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
