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[DOI] [PMC free article] [PubMed] [Google Scholar] Bruderer R, Bernhardt OM, Gandhi T, Xuan Y, Sondermann J, Schmidt M, Gomez-Varela D, Reiter L Optimization of experimental parameters in data-independent mass spectrometry significantly increases depth and reproducibility of results

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Supplementing it reverses some of that decline

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For severe deficiency, patients get 1,000 mcg daily for the first week