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Cabanillas ME, de Souza JA, Geyer S, Wirth LJ, Menefee ME, Liu SV, et al

This format therefore serves research into intranasal administration, drawing on preclinical data and physicochemical reasoning, rather than on a confirmed clinical precedent

Low serum folate in elderly patients has been found to result in impaired spatial copying skills, abstraction performance, and non-verbal abstract thinking, in comparison to age-matched individuals with normal serum folate concentration (, )

Dosing should be individualized based on patient response and laboratory markers

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