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Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders

The amino-terminus and residues in transmembrane domains 7, 9 and 10 have important roles in carnitine recognition [98]

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Furthermore, the elevated AC signal (C16, C18:2, C18:1, C16:1-OH/C14:1-DC, C20:4) increased linearly with decreasing left ventricular ejection fraction, which is a defining clinical characteristic of heart failure

These cytokines can also cross the blood-brain barrier, driving the severe neuroinflammation responsible for the profound cognitive dysfunction, memory loss, and "brain fog" reported by so many patients

"L-Carnitine: Overview, Uses, and Side Effects." WebMD
