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DGAT2 and GPAT4 targeting the surface of LDs is important for LD expansion

Dual inhibition of GGCT and xCT induces ferroptosis through cysteine depletion and redox collapse To investigate the mechanism by which the combination of pro-GA and erastin induces ferroptosis, we assessed whether the mechanism involved disrupting intracellular redox homeostasis

Lpez-Alarcn C, Fuentes-Lemus E, Figueroa JD, Dorta E, Schneich C, Davies MJ

37 , 723741.e6 (2025)

Conversely, acute or chronic inflammation and stress have been found to increase the throughput of the kynurenine pathway, leading to an increase in tryptophans conversion to kynurenine [32,55]