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Finally, the susceptibility of an individual to methotrexate MIOM may be influenced by polymorphisms in genes encoding proteins and enzymes involved in MTX transport, metabolism, folate metabolism or neutralisation of reactive oxygen species (ROS)

Notably, we observed an enrichment of proteins involved in binding function, cofactor requirement and environment interaction in the cardiac tissues of db/db mice compared to NaHS-treated db/db mice (Fig

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