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However, in ME2 homozygously deleted PDAC cell lines, its isoenzyme ME3 plays the compensatory roles for intracellular NADPH homeostasis

Many flavonoids (including hesperetin from citrus, farrerol from rhododendron, and the flavones apigenin and luteolin from chamomile and celery) activate the Keap1Nrf2ARE pathway, which leads to upregulation of cytoprotective enzymes such as heme oxygenase-1 and superoxide dismutase (17, 26)

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M., Cui, W

10.1079/WPS200445 104

Within the organ system, ROS generation can worsen to either excess or deficiency, for example, in cases of mitochondrial dysfunction or ferroptosis, which tip the balance from survival to cell death (Lewerenz et al
