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Variability in NFE2L2 and KEAP1 mutations, coupled with nongenetic mechanisms such as p62/SQSTM1 accumulation, results in highly variable NRF2 activity across tumors, complicating the unification of therapeutic approaches [5, 56]

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Romina: A Powerful Strawberry with In Vitro Efficacy against Uterine Leiomyoma Cells

assessed antioxidant capacity through the Folin-Ciocalteau and Trolox equivalent antioxidant capacity assays, noting that pH had a more significant impact on antioxidant capacity than the addition of cysteine

However, this classification becomes ambiguous in the context of probiotics, as many defensive genes are indispensable for probiotic survival and function and are increasingly recognized as health-associated factors rather than true virulence determinants

Implications for treatment