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This change is particularly relevant as although Firmicutes is recognized as being composed of fiber fermenting species and usually predominant in the caeca of chickens [54, 55], Actinobacteria members have been proposed as probiotic, especially useful in poultry farming due to their role in short chain fatty acid production [56]

TGF1 is one of the major repressors of GCL expression leading to lower levels of GSH [9]

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, Helicobacter pylori , Lactobacillus spp

Peer review Peer review information Nature Communications thanks Jos Pedro Friedmann Angeli and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Once your levels are optimized, many patients transition to a monthly maintenance schedule