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Phenotypic heterogeneity within bacterial populations has also been demonstrated as a factor that can contribute to resistance, where QS-deficient cheater cells exploit QS-dependent public goods, such as virulence factors, without contributing to signal production, thereby reducing the selective pressure imposed by QSIs [220]

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Dyskinesia and motor fluctuations are other reported adverse events of levodopa after prolonged usage that can significantly impact the quality of life in the long term [14, 18]

Unfortunately, its effectiveness can be limited particularly during tumor recurrence by its toxicity to renal proximal tubule cells (reviewed in Zhang and Hanigan, 2003)

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