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GPX4 inhibition using RSL3 is a successful anti-tumor agent in vitro, but its limited bioavailability makes it challenging to use in vivo

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doi:10.2174/138161211796196954

The selectivity of FOXO4-DRI appears to be a major advantage: FOXO4-DRI peptide is particularly compelling due to its ability to disrupt the FOXO4-p53 interaction , a critical regulator of cellular senescence

This approach takes advantage of the strong interaction of glutathione towards metal ions (Cu in this case), leading to the formation of a Cu-GSH complex, avoiding electrode fouling by chloride ions (Cl ) present in the solution, which in turn caused a sharp reduction in the peak current of CuCl

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