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The study was conducted in two parts: a 1-week, double-blind, randomized inpatient phase with daily assessments, and a 2-week open-label outpatient phase

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The follow-up study in a thromboembolic rat stroke model, where tissue plasminogen activator (t-PA) was administered first for clot lysis followed by nano-SOD/CAT, both via the carotid artery, demonstrated the protective effect of the treatment