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In canonical Wnt/-catenin signaling, the secreted Wnt ligands bind with the Frizzled receptor, which further inactivates glycogen synthase kinase-3 (GSK-3), which is an enzyme responsible for the ubiquitination-mediated degradation of -catenin 4,5

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doi: 10.1007/s00213-017-4730-6 109 ShimonIRudmanYManisterskiYGorshteinAMasriHDuskin-BitanH