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In coccidioidomycosis spherule formation is required for pathogenicity [9], as exemplified by two mutant strains [10, 11]
Furthermore, a chronic inflammatory state in the nervous system intensifies with age, leading to increased microglial activation and elevated levels of proinflammatory cytokines, such as tumor necrosis factoralpha (TNF) and interleukin1 beta (IL1), detectable even preclinically [63, 64]

Cancer Prev Res 8:165

& Ouwerkerk-Mahadevan, S
Collectively, these clinical studies underscore the diverse therapeutic potential of natural compounds in addressing AD pathology and related symptoms

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