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32 , 50 , 52 , 55 MM cells in the BM niche can also simultaneously express enzymes of the canonical or noncanonical ADO pathway, either on the surface of cells or on extracellular vesicles

Metabolic health may also be affected, as specific peptides may cause fluctuations in blood sugar levels, impacting individuals with pre-existing conditions like diabetes

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In vitro , they found that NNMT knockdown significantly lowers hepatocyte glucose output (50%) and that NNMT overexpression significantly increases hepatocyte glucose output (1.4-fold) [14]

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