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- with prolonged therapy: anatomical signs of pathology of the valvular apparatus of the heart (such as thickening of the valve leaflet , narrowing of the valve lumen, mixed pathology (narrowing and stenosis of the valve), confirmed by an echocardiographic study (EchoCG), conducted prior to the start of therapy

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If our red blood cells are destroyed or lysed by PFO, there will be no way for oxygen to travel to parts of our body and our cells will die

More recent studies have evaluated oral PTX in conjunction with oral antioxidants, intralesional PTX and intralesional verapamil with varying results (34,35)