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28,29 If the fragments are additionally depressed, the disc containment is impaired and even nucleus material can be lost into the underlying trabecular bone

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Chen P-M, Tsokos GC

Furthermore, the inhibition of DHODH also reduces the levels of vital antioxidants, such as GSH, which are necessary for counteracting lipid peroxides, thus rendering cells more prone to oxidative stress and lipid damage (173,174)

System xc cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS