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These observations are in line with results reported in a prior study, suggesting a potential therapeutic role for sakuranetin in modulating BDNF and TrkB levels in the context of seizures 39,50

The complicated ROS elimination system comprises endogenous antioxidant enzymes, mainly including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), as well as low-molecular-weight scavengers, including vitamins, -carotene, coenzyme Q, selenium and zinc

and Mohamed, H
doi: 10.2147/DDDT.S79458 198 HunterDJBierma-ZeinstraS

Another study reported that melatonin upregulated the Nrf2 signaling pathway by activating the MDM2-p53-p21 signaling cascade (Tao et al., 2022[220])
